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KMID : 0383419680090010053
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Korean Modern Medical Journal
1968 Volume.9 No. 1 p.53 ~ p.54
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Cardiac Catecholamine and Serotonin Contents and Responses to These Amines in Various Species of Animals
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Chung Kyung-Han
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Abstract
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Accumulated evidence indicates that catecholamines are normally synthesized, stored and degraded within the myocardium and it has been also well documented that the store of catecholamine in the myocardium is involved in maintaining normal cardiac functions. Lee and Shideman(1959) observed that depletion of myocardial catecholamines resulted in depression of cardiac contractility and suggested that the cardiac stores of these amines are important in maintaining normal contW_, ractility. In addition, Lee et al. (1966) demonostrated that the increased cardiac function from per pretreatment with thyroxine is largely dependent upon its capacity to cause an increase in concentration. of cardiac catecholamines.
The present experiment was undertaken to examine and compare the concentrations and distributions of myocardial catecholamines among various species of animals. The serotonin content in hearts of these animals was also determined.
Animals employed in this experiment were the cat, dog,. cow, pig and rabbit (Mammalia),. chicken and duck (Ayes), turtle (Reptilia), frog (Amphibia), fish (Pisces) and clam (Mollusca). The animals, except cows and pigs, were sacrificed by decapitating, or by a blow on the head and then the heart rapidly removed. The hearts of cows and pigs were freshly obtained from the butchery. The catecholamine and serotonin contents were determined by the spectrophotoflu orometric procedure described by Shore and Olin (1958), and by Bogdanski et al. (1950, respectively.
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